TACC

Transforming acidic coiled-coil (TACC), an evolutionally conserved protein family, has been shown to be involved in the process of mitotic spindle is assembly by the coordinated action of centrosomes and kinetochore microtubules, ultimately enhancing microtubule polymerization. TACC3 was originally identified within a translocation breakpoint region that was associated with multiple myelomas, and subsequent studies have indicated that it is aberrantly expressed in various cancers, and thus considered to be a potential molecular target for cancer chemotherapy[1].


[1] R. Yao et al. A small compound targeting TACC3 revealed its different spatiotemporal contributions for spindle assembly in cancer cells. Oncogene. 2014 Aug 14;33(33):4242-52.

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Axon ID Name Description From price
2474 SPL-B Inhibitor of TACC3 that inhibits nucleation of centrosome microtubules €125.00

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