Ispinesib - SB 715992

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2446

CAS [336113-53-2]

MF C30H33ClN4O2
MW 517.06

  • Purity: 99%
  • Optical purity: 100% e.e.
  • Soluble in DMSO and Ethanol



The first potent, highly specific small-molecule inhibitor of the human kinesin spindle protein (KSP or KIF11 or Eg5), that induces mitosis-phase (M-phase) arrest followed by apoptosis in either the M-phase (via mitotic catastrophe) or G1-phase of the cell-cycle. Ispinesib alters the ability of KSP to bind to microtubules and inhibits its movement by preventing the release of ADP without preventing the release of the KSP−ADP complex from the microtubule.

Size Unit Price Stock
5 mg €110.00 In Stock
25 mg €380.00 In Stock
Special Offers
Size Unit Price Stock
2 x 5 mg €160.00 In Stock
2 x 25 mg €560.00 In Stock
Need more? Bulk Inquiry

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Please wait...