Dimethylenastron - Eg5 inhibitor III

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2439

CAS [863774-58-7]

MF C16H18N2O2S
MW 302.39

  • Purity: 98%
  • Optical purity: Racemate
  • Soluble in DMSO

Dimethylenastron

Description

Specific potent and cell-permeable inhibitor of the mitotic motor Eg5 (a.k.a. kinesin-5 or KSP; IC50 value 200 nM). Dimethylenastron proved to be >100-times more potent than monastrol, both in vitro and with arresting mitosis of cultured cells. Capable of halting cell cycle progression in mitosis and of inducing apoptosis. Dimethylenastron activates the PI3K/Akt pathway, which in turn causes transcriptional up-regulation of Hsp70.
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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