KHS101 hydrochloride is a brain-penetrable TACC3 inhibitor known to enhance neuronal differentiation (EC50 value of 1 μM in cultured rat NPCs) and inhibit cell cycle progression and proliferation. KHS101 hydrochloride works indirectly on HIF complex formation by destabilizing both TACC3 and the HIF component HIF-1α. KHS101 hydrochloride suppresses proliferation, migration, and invasive capabilities of breast cancer cells, EMT process, and mammosphere forming capability, alters cell cycle progression, and induces apoptosis.

KEYWORDS: SKHS101 hydrochloride | supplier | TACC3 inhibitor | KHS 101 hydrochloride | KHS-101 hydrochloride | CAS [1784282-12-7] | [1262770-73-9] | Microtubules | TACC | Inhibitor | Proteins | TACC3 | NPC | HIF | HIF-1α | Breast cancer