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Axon 2258
CAS [881970-80-5]
MF C21H13FN2O2SMW 376.40
MDK expression inhibitor; iMDK inhibits specifically and dose-dependently the expression of Midkine (MDK) in H441 lung adenocarcinoma cells, but does not inhibit PTN (Pleiotrophin), which has considerable homology to MDK. iMDK induces apoptotosis in MDK-expressing H441 lung adenocarcinoma cells by suppression of the PI3K/Akt pathway but not the MAPK pathway. iMDK does not inhibit another growth factor VEGF.
KEYWORDS: iMDK | Midkine expression inhibitor | CAS [881970-80-5] | NF-κB Pathway | Midkine | Inhibitor | Proteins | cytokine | NF-êB | PI3K | Akt | Apoptosis | Carcinoma | Lung cancer
3-(2-(4-fluorobenzyl)imidazo[2,1-b]thiazol-6-yl)-2H-chromen-2-one
[881970-80-5]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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