Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2258

CAS [881970-80-5]

MW 376.40

  • Purity: 99%
  • Soluble in DMSO



MDK expression inhibitor; iMDK inhibits specifically and dose-dependently the expression of Midkine (MDK) in H441 lung adenocarcinoma cells, but does not inhibit PTN (Pleiotrophin), which has considerable homology to MDK. iMDK induces apoptotosis in MDK-expressing H441 lung adenocarcinoma cells by suppression of the PI3K/Akt pathway but not the MAPK pathway. iMDK does not inhibit another growth factor VEGF.

KEYWORDS: iMDK | Midkine expression inhibitor | CAS [881970-80-5] | NF-κB Pathway | Midkine | Inhibitor | Proteins | cytokine | NF-êB | PI3K | Akt | Apoptosis | Carcinoma | Lung cancer

Size Unit Price Stock
5 mg €120.00 In Stock
25 mg €420.00 In Stock
Special Offers
Size Unit Price Stock
2 x 5 mg €200.00 In Stock
Need more? Bulk Inquiry

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Please wait...