TCID

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2333

CAS [30675-13-9]

MF C9H2Cl4O2
MW 283.92

Purity: 99%
Soluble in DMSO

TCID

Description

Potent, cell permeant inhibitor of UCHL3 (IC50 value 0.6 µM) with 125-fold selectivity over UCHL1. Specific inhibition of UCHL3 with TCID diminished GlyT2 ubiquitination in brainstem and spinal cord primary neurons and may be beneficial in several human disorders, including neuromotor deficiencies (startle disease, myoclonus), pain and epilepsy.

Y. Liu et al. Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem. Biol. 2003, 10, 837-846.

J. de Juan-Sanz et al. Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster. PLoS One. 2013, 8, e58863.

Potent inhibitor of UCHL3 with >100-fold selectivity over UCHL1

Chemical name

4,5,6,7-tetrachloro-1H-indene-1,3(2H)-dione

Parent CAS No.

[30675-13-9]

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Size	Unit Price	Stock
10 mg	€80.00	In Stock
50 mg	€280.00	In Stock

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