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LDN 57444

Axon 2449
CAS:  668467-91-2
Purity:  99%
  • Soluble in DMSO
  • MF:  C17H11Cl3N2O3
  • MW:  397.64

Description

Reversible, competitive inhibitor of UCH-L1 (Ki value 0.40 µM; IC50 values 0.88 µM and 25 µM for UCH-L1 and UCH-L3 inhibition, respectively), that promotes proliferation of H1299 NSCLC cells and SH-SY5Y neuroblastoma cells. A usefull tool to study the role of UCH-L1 in Parkinson’s disease, cancer, and neuropathic pain.

More Information

Parent CAS No. 668467-91-2
Chemical Name 3-(acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one
SMILES N1(CC2=CC(Cl)=CC=C2Cl)C2=C(C=C(Cl)C=C2)/C(=NOC(C)=O)/C1=O
MFCD MFCD09037562
InChi InChI=1S/C17H11Cl3N2O3/c1-9(23)25-21-16-13-7-12(19)3-5-15(13)22(17(16)24)8-10-6-11(18)2-4-14(10)20/h2-7H,8H2,1H3/b21-16+
InChiKey OPQRFPHLZZPCCH-LTGZKZEYSA-N
CID 51537051
Short Description UCH-L1 inhibitor

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