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Bortezomib
- PS 341 - Velcade
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C19H25BN4O4
- MW: 384.24
Description
More Information
| Parent CAS No. | 179324-69-7 |
|---|---|
| Chemical Name | (R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butan-2-ylboronic acid |
| SMILES | C1N=C(C(=O)N[C@@H](CC2C=CC=CC=2)C(=O)N[C@@H](CC(C)C)B(O)O)C=NC=1 |&1:6,17,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1 |
| InChiKey | GXJABQQUPOEUTA-RDJZCZTQSA-N |
| CID | 387447 |
| Short Description | Proteasome inhibitor |
References
- P Bonvini et al. Bortezomib-mediated 26S proteasome inhibition causes cell-cycle arrest and induces apoptosis in CD-30+ anaplastic large cell lymphoma. Leukemia 2007, 21(4), 838–842.
- S Williams et al. Differential effects of the proteasome inhibitor bortezomib on apoptosis and angiogenesis in human prostate tumor xenografts. Mol. Cancer Ther. 2003, 2, 835-843.
- Y Ling et al. Mechanisms of Proteasome Inhibitor PS-341-induced G2-M-Phase Arrest and Apoptosis in Human Non-Small Cell Lung Cancer Cell Lines. Clin. Cancer Res. 2003, 9, 1145-1154.
- A Corso et al. Bortezomib plus dexamethasone can improve stem cell collection and overcome the need for additional chemotherapy before autologous transplant in patients with myeloma. Leukemia & Lymphoma 2010, 51(2), 236-242.
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