M-3258
Axon 3724
CAS:
2285330-15-4
- Optical Purity: 0.99
- Soluble in DMSO
- MF: C17H20BNO5
- MW: 329.16
Description
M-3258 is an orally-bioavailable potent and selective inhibitor of the immunoproteasome subunit LMP7 demonstrating >500-fold selectivity against β1c, β2c, β5c, β1i and β2i. M3258 displayed favorable pharmacokinetics and demonstrated strong LMP7 inhibition and anti-tumor activity in several multiple myeloma xenografts, including models that were refractory to Bortezomib.
More Information
| Parent CAS No. | 2285330-15-4 |
|---|---|
| Chemical Name | (R)-2-(benzofuran-3-yl)-1-((1S,2R,4R)-7-oxabicyclo[2.2.1]heptane-2-carboxamido)ethylboronic acid |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | N(C(=O)[C@H]1[C@H]2O[C@H](CC2)C1)[C@H](B(O)O)CC1C2C=CC=CC=2OC=1 |&1:3,4,6,10,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C17H20BNO5/c20-17(13-8-11-5-6-15(13)24-11)19-16(18(21)22)7-10-9-23-14-4-2-1-3-12(10)14/h1-4,9,11,13,15-16,21-22H,5-8H2,(H,19,20)/t11-,13-,15+,16+/m1/s1 |
| InChiKey | RFQDLTYXNINJON-OYNZBZHQSA-N |
| CID | 138319683 |
| Short Description | Proteasome inhibitor |
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