Eeyarestatin I - ES1 | ERAD inhibitor 1 | p97 inhibitor 1

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1798

CAS [412960-54-4]

MF C27H25Cl2N7O7
MW 630.44

Purity: 98%
Soluble in DMSO

Eeyarestatin I

Description

Potent inhibitor of endoplasmic reticulum associated protein degradation (ERAD). Specifically targets the p97-associated deubiquinating process (PAD) and inhibits ataxin-3 (atx3)-dependent deubiquitination

BC Cross et al. Eeyarestatin I inhibits Sec61-mediated protein translocation at the endoplasmic reticulum. J. Cell Sci. 2009, 122(Pt 23), 4393-4400.

MO Aletrari et al. Eeyarestatin 1 interferes with both retrograde and anterograde intracellular trafficking pathways. PLoS One. 2011, 6(7), e22713.

Q Wang et al. Inhibition of p97-dependent Protein Degradation by Eeyarestatin I. J. Biol. Chem. 2008, 283, 7445-7454.

Inhibitor of endoplasmic reticulum associated protein degradation (ERAD)

Chemical name

3-(4-chlorophenyl)-1-(3-(4-chlorophenyl)-5,5-dimethyl-1-(2-(2-(3-(5-nitrofuran-2-yl)allylidene)hydrazinyl)-2-oxoethyl)-2-oxoimidazolidin-4-yl)-1-hydroxyurea

Parent CAS No.

[412960-54-4]

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Size	Unit Price	Stock
2 mg	€80.00	In Stock
5 mg	€120.00	In Stock
25 mg	€420.00	In Stock

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Eeyarestatin I - ES1 | ERAD inhibitor 1 | p97 inhibitor 1

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Eeyarestatin I - ES1 | ERAD inhibitor 1 | p97 inhibitor 1

Description

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Parent CAS No.

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