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ML 323
- Soluble in DMSO
- MF: C23H24N6
- MW: 384.48
Description
Selective, reversible and highly potent inhibitor of the USP1–UAF1 deubiquitinase complex that links deubiquitination to DNA damage responses (IC50 values of 76 nM in a ubiquitin-rhodamine (Ub-Rho) assay and 174 nM and 820 nM in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) and monoubiquitinated PCNA (Ub-PCNA) as substrates, respectively). ML323 effectively sensitized cisplatin-resistant NSCLC H596 cells and U2OS osteosarcoma cells to cisplatin since it simultaneously targets two major DNA damage response pathways (TLS and FA) by inhibiting a common deubiquitinase.
More Information
| Parent CAS No. | 1572414-83-5 |
|---|---|
| Chemical Name | N-(4-(1H-1,2,3-Triazol-1-yl)benzyl)-2-(2-isopropylphenyl)-5-methylpyrimidin-4-amine |
| SMILES | C1(C2=CC=CC=C2C(C)C)=NC=C(C)C(NCC2=CC=C(N3C=CN=N3)C=C2)=N1 |
| MFCD | N.A. |
| InChi | InChI=1S/C23H24N6/c1-16(2)20-6-4-5-7-21(20)23-24-14-17(3)22(27-23)25-15-18-8-10-19(11-9-18)29-13-12-26-28-29/h4-14,16H,15H2,1-3H3,(H,24,25,27) |
| InChiKey | VUIRVWPJNKZOSS-UHFFFAOYSA-N |
| CID | 60167849 |
| Short Description | USP1–UAF1 inhibitor |
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