ML 323

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2309

CAS [1572414-83-5]

MF C23H24N6
MW 384.48

  • Purity: 100%
  • Soluble in DMSO

ML 323


Selective, reversible and highly potent inhibitor of the USP1–UAF1 deubiquitinase complex that links deubiquitination to DNA damage responses (IC50 values of 76 nM in a ubiquitin-rhodamine (Ub-Rho) assay and 174 nM and 820 nM in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) and monoubiquitinated PCNA (Ub-PCNA) as substrates, respectively). ML323 effectively sensitized cisplatin-resistant NSCLC H596 cells and U2OS osteosarcoma cells to cisplatin since it simultaneously targets two major DNA damage response pathways (TLS and FA) by inhibiting a common deubiquitinase.

KEYWORDS: ML 323 | USP1-UAF1 inhibitor | ML323 |CAS[1572414-83-5] | Ubiquitin peptides | Deubiquitinase | Inhibitor | DNA damage |  cisplatin-resistant | TLS | FA

Size Unit Price Stock
5 mg €95.00 In Stock
25 mg €305.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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