ONX 0914 - PR 957

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2199

CAS [960374-59-8]

MF C31H40N4O7
MW 580.67

  • Purity: 98%
  • Optical purity: Optically pure
  • Soluble in 0.1N HCl(aq) and DMSO

ONX 0914

Description

Selective inhibitor of LMP7, the chymotrypsin-like subunit of the immunoproteasome. ONX 0914 blocks the production of cytokines IL-23, TNF-α, and IL-6 in a NF-κB independent manner, and attenuates progression of experimental arthritis in mouse models.
ONX 0914 induces an anti-inflammatory response at doses less than one tenth of the maximum tolerated dose, in contrast to nonselective inhibitors, such as bortezomib (Axon 1810) and carfilzomib.

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2 mg €95.00 In Stock
5 mg €145.00 In Stock
25 mg €505.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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