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Sabizabulin
- VERU111
- Soluble in DMSO
- MF: C21H19N3O4
- MW: 377.39
Description
Sabizabulin is an orally bioavailable and highly potent inhibitor of tubulin polymerization with an average IC50 value of 3.8 nM (five tested cancer cell lines).
More Information
| Parent CAS No. | 1332881-26-1 |
|---|---|
| Chemical Name | (2-(1H-Indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone |
| SMILES | C1(OC)C(OC)=C(OC)C=C(C(C2=CNC(C3C4C=CC=CC=4NC=3)=N2)=O)C=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C21H19N3O4/c1-26-17-8-12(9-18(27-2)20(17)28-3)19(25)16-11-23-21(24-16)14-10-22-15-7-5-4-6-13(14)15/h4-11,22H,1-3H3,(H,23,24) |
| InChiKey | WQGVHOVEXMOLOK-UHFFFAOYSA-N |
| CID | 53379371 |
| Short Description | Tubulin inhibitor |
References
- J Chen et al. Discovery of novel 2-aryl-4-benzoyl-imidazole (ABI-III) analogues targeting tubulin polymerization as antiproliferative agents. J Med Chem. 2012 Aug 23;55(16):7285-9.
- VK Kashyap et al. VERU-111 suppresses tumor growth and metastatic phenotypes of cervical cancer cells through the activation of p53 signaling pathway. Cancer Lett. 2020 Feb 1;470:64-74.
- RI Krutilina et al. Sabizabulin, a Potent Orally Bioavailable Colchicine Binding Site Agent, Suppresses HER2+ Breast Cancer and Metastasis. Cancers (Basel). 2022 Oct 29;14(21):5336.
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