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Enzymes
Transferases
Kinases (Serine-Threonine Specific Protein)
IRE
MKC-3946

MKC-3946

Based on 7 reference(s) in Google Scholar 8 10 7

Axon 3670

CAS [1093119-54-0]

MF C21H20N2O3S
MW 380.46

Purity: 99%
Soluble in 0.1N HCl(aq), DMSO and EtOH

MKC-3946

Description

MKC-3946 is a potent and selective IRE1α inhibitor with an IC50 value of 0.39 μM.

Keywords: MKC-3946 | Supplier | IRE1α inhibitor | MKC3946 | MKC 3946 | CAS [1093119-54-0] | DNA-RNA | IRE | Inhibitor | Enzymes | Multiple myeloma | Inositol-requiring enzyme 1α | ER stress | XBP1 | UPR

M Mimura et al. Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma. Blood. 2012 Jun 14;119(24):5772-81.

M Sanches et al. Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors. Nat Commun. 2014 Aug 28;5:4202.

Apoptosis Cell Signaling & Oncology EC 2.7.11.1 IRE

Potent and selective IRE1α inhibitor

Chemical name

2-Hydroxy-6-(5-(4-methylpiperazine-1-carbonyl)thiophen-2-yl)-1-naphthaldehyde

Parent CAS No.

[1093119-54-0]

Order

Size	Unit Price	Stock
5 mg	€120.00	In Stock
25 mg	€420.00	In Stock

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