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XY028-140
- MS140
- Soluble in DMSO
- MF: C39H40N10O7
- MW: 760.8
Description
XY028-140 is a potent and selective CDK4/6 inhibitor-degrader (PROTAC) with IC50 values of 0.38 nM and 0.28 nM against CDK4/cyclin D1 and CDK6/cyclin D1, respectively. XY028-140 potently and selectively both inhibited and degraded CDK4/6 kinases in CDK4/6i-S tumor cells by targeting them to the CRL4-CRBN-E3 ubiquitin complex.
More Information
| Parent CAS No. | 2229974-83-6 |
|---|---|
| Chemical Name | 4-(2-(4-(6-(6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)pyridin-3-yl)piperazin-1-yl)-2-oxoethylamino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione |
| SMILES | C1(=O)N(C2CCCC2)C2N=C(NC3C=CC(N4CCN(C(=O)CNC5C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C=6C=CC=5)CC4)=CN=3)N=CC=2C(C)=C1C(C)=O |
| MFCD | N.A. |
| InChi | InChI=1S/C39H40N10O7/c1-21-26-19-42-39(45-34(26)48(23-6-3-4-7-23)37(55)32(21)22(2)50)43-29-12-10-24(18-41-29)46-14-16-47(17-15-46)31(52)20-40-27-9-5-8-25-33(27)38(56)49(36(25)54)28-11-13-30(51)44-35(28)53/h5,8-10,12,18-19,23,28,40H,3-4,6-7,11,13-17,20H2,1-2H3,(H,44,51,53)(H,41,42,43,45) |
| InChiKey | IWFNIKIERKCKFZ-UHFFFAOYSA-N |
| CID | 134605838 |
| Short Description | CDK4/6 inhibitor |
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