MS140

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 3535

CAS [2229974-83-6]

MF C39H40N10O7
MW 760.80

  • Purity: 98%
  • Soluble in DMSO

MS140

Description

MS140 is a potent and selective CDK4/6 inhibitor-degrader (PROTAC) with IC50 values of 0.38 nM and 0.28 nM against CDK4/cyclin D1 and CDK6/cyclin D1, respectively. MS140 potently and selectively both inhibited and degraded CDK4/6 kinases in CDK4/6i-S tumor cells by targeting them to the CRL4-CRBN-E3 ubiquitin complex.

KEYWORDS: MS140 | Supplier | CDK4/6 inhibitor | MS 140 | MS-140 | CAS [2229974-83-6] | [2676966-40-6] | Cyclin Dependent (CDK) | CDK | Inhibitor | Enzymes | Metastatic breast cancer | PROTAC

Potent and selective CDK4/6 inhibitor; PROTAC

Chemical name

4-(2-(4-(6-(6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)pyridin-3-yl)piperazin-1-yl)-2-oxoethylamino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

Parent CAS No.

[2229974-83-6]

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5 mg €100.00 In Stock
25 mg €320.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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