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Axon 3535
CAS [2229974-83-6]
MF C39H40N10O7MW 760.80
XY028-140 is a potent and selective CDK4/6 inhibitor-degrader (PROTAC) with IC50 values of 0.38 nM and 0.28 nM against CDK4/cyclin D1 and CDK6/cyclin D1, respectively. XY028-140 potently and selectively both inhibited and degraded CDK4/6 kinases in CDK4/6i-S tumor cells by targeting them to the CRL4-CRBN-E3 ubiquitin complex.
KEYWORDS: XY028-140 | CDK4/6 inhibitor | MS140 | XY028140 | XY028 140 | MS 140 | MS-140 | CAS [2229974-83-6] | Cyclin dependent (CDK) | CDK | Inhibitor | Enzymes | Metastatic breast cancer | PROTAC
4-(2-(4-(6-(6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)pyridin-3-yl)piperazin-1-yl)-2-oxoethylamino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
[2229974-83-6]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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