XY028-140 - MS140

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 3535

CAS [2229974-83-6]

MF C39H40N10O7
MW 760.80

  • Purity: 98%
  • Soluble in DMSO



XY028-140 is a potent and selective CDK4/6 inhibitor-degrader (PROTAC) with IC50 values of 0.38 nM and 0.28 nM against CDK4/cyclin D1 and CDK6/cyclin D1, respectively. XY028-140 potently and selectively both inhibited and degraded CDK4/6 kinases in CDK4/6i-S tumor cells by targeting them to the CRL4-CRBN-E3 ubiquitin complex.

KEYWORDS: XY028-140 | CDK4/6 inhibitor | MS140 | XY028140 | XY028 140 | MS 140 | MS-140 | CAS [2229974-83-6] | Cyclin dependent (CDK) | CDK | Inhibitor | Enzymes | Metastatic breast cancer | PROTAC

Potent and selective CDK4/6 inhibitor; PROTAC

Chemical name


Parent CAS No.


Size Unit Price Stock
5 mg €120.00 In Stock
25 mg €420.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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