LY-364947 - HTS466284

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 3404

CAS [396129-53-6]

MF C17H12N4
MW 272.30

Purity: 99%
Soluble in DMSO

LY-364947

Description

LY-364947 is a potent, selective and ATP-competitive TGF-βR 1 inhibitor with an IC50 value of 59 nM.

KEYWORDS: LY-364947 | supplier | ALK5 inhibitor | HTS466284 | LY364947 | LY 364947 | HTS 466284 | HTS-466284 | CAS [396129-53-6] | TGF-β | TGF-βR | Antagonist | Receptors | Smad3 | ALK5

JS Sawyer et al. Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain. J Med Chem. 2003 Sep 11;46(19):3953-6.

J Singh et al. Successful shape-based virtual screening: the discovery of a potent inhibitor of the type I TGFbeta receptor kinase (TbetaRI). Bioorg Med Chem Lett. 2003 Dec 15;13(24):4355-9.

SB Peng et al. Kinetic characterization of novel pyrazole TGF-beta receptor I kinase inhibitors and their blockade of the epithelial-mesenchymal transition. Biochemistry. 2005 Feb 22;44(7):2293-304.

HY Li et al. Dihydropyrrolopyrazole transforming growth factor-beta type I receptor kinase domain inhibitors: a novel benzimidazole series with selectivity versus transforming growth factor-beta type II receptor kinase and mixed lineage kinase-7. J Med Chem. 2006 Mar 23;49(6):2138-42.

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology TGF-β RSTK class I; EC 2.7.11.30 TGF-βR

Potent, selective and ATP-competitive TGF-βR 1 inhibitor

Chemical name

4-(3-(Pyridin-2-yl)-1H-pyrazol-4-yl)quinoline

Parent CAS No.

[396129-53-6]

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10 mg	€90.00	In Stock
50 mg	€300.00	In Stock

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LY-364947 - HTS466284

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LY-364947 - HTS466284

Description

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