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LY-364947
- HTS466284
- Soluble in DMSO
- MF: C17H12N4
- MW: 272.3
Description
LY-364947 is a potent, selective and ATP-competitive TGF-βR 1 inhibitor with an IC50 value of 59 nM.
More Information
| Parent CAS No. | 396129-53-6 |
|---|---|
| Chemical Name | 4-(3-(Pyridin-2-yl)-1H-pyrazol-4-yl)quinoline |
| SMILES | C12C=CC=CC1=C(C1=CNN=C1C1C=CC=CN=1)C=CN=2 |
| MFCD | MFCD00800758 |
| InChi | InChI=1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21) |
| InChiKey | IBCXZJCWDGCXQT-UHFFFAOYSA-N |
| CID | 447966 |
| Short Description | ALK5 inhibitor |
References
- JS Sawyer et al. Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain. J Med Chem. 2003 Sep 11;46(19):3953-6.
- J Singh et al. Successful shape-based virtual screening: the discovery of a potent inhibitor of the type I TGFbeta receptor kinase (TbetaRI). Bioorg Med Chem Lett. 2003 Dec 15;13(24):4355-9.
- SB Peng et al. Kinetic characterization of novel pyrazole TGF-beta receptor I kinase inhibitors and their blockade of the epithelial-mesenchymal transition. Biochemistry. 2005 Feb 22;44(7):2293-304.
- HY Li et al. Dihydropyrrolopyrazole transforming growth factor-beta type I receptor kinase domain inhibitors: a novel benzimidazole series with selectivity versus transforming growth factor-beta type II receptor kinase and mixed lineage kinase-7. J Med Chem. 2006 Mar 23;49(6):2138-42.
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