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YW2065
- Soluble in DMSO
- MF: C20H15BrN4O
- MW: 407.26
Description
The dual-functional compound YW2065 is a potent inhibitor of the Wnt/β-catenin signaling pathway (IC50 value of 2.3 nM) and an AMPK activator. YW2065 may achieve its dual activities through the mechanism of Axin-1 stabilization. YW2065 demonstrated favorable PK properties and suppressed tumor growth in a xenograft mouse model.
More Information
| Parent CAS No. | 2131223-85-1 |
|---|---|
| Chemical Name | 1-(2-Bromophenyl)-5-methyl-N-(quinolin-2-yl)-1H-pyrazole-4-carboxamide |
| SMILES | C1C=C(Br)C(N2N=CC(C(NC3N=C4C=CC=CC4=CC=3)=O)=C2C)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C20H15BrN4O/c1-13-15(12-22-25(13)18-9-5-3-7-16(18)21)20(26)24-19-11-10-14-6-2-4-8-17(14)23-19/h2-12H,1H3,(H,23,24,26) |
| InChiKey | ATYUYECWVYSPBS-UHFFFAOYSA-N |
| CID | 137375527 |
| Short Description | Wnt/β-catenin inhibitor/AMPK activator |
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