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Rucaparib camsylate
- Parent CAS: 283173-50-2
- Soluble in DMSO
- MF: C19H18FN3O.C10H16O4S
- MW: 555.66
Description
A PARP 1 inhibitor with potential chemosensitizing, radiosensitizing and antineoplastic activities; selectively binds to PARP1 (Ki=1.4 nM) and inhibits PARP1-mediated DNA repair, thereby enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. Also available as the phosphate salt AG 014699 (Axon 1529).
More Information
| Parent CAS No. | 283173-50-2 |
|---|---|
| Chemical Name | 8-Fluoro-5-(4-((methylamino)methyl)phenyl)-2,3,4,6-tetrahydro-1H-azepino[5,4,3-cd]indol-1-one ((1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonate |
| MFCD | N.A. |
| Short Description | PARP1 inhibitor |
References
- HD Thomas et al. Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial. Mol. Cancer Ther. 2007, 6(3), 945-56.
- P Plummer et al. Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors. Clin Cancer Res. 2008, 14(23), 7917-23.
- M Ali et al. Vasoactivity of AG014699, a Clinically Active Small Molecule Inhibitor of Poly(ADP-ribose) Polymerase: a Contributory Factor to Chemopotentiation In vivo? Clin. Cancer Res. 2009, 15(19), 6106-6112.
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