Bulk Inquiry
GNE 317
- Soluble in DMSO
- MF: C19H22N6O3S
- MW: 414.48
Description
GNE 317 is a brain-penetrant PI3K α-isoform inhibitor with a Ki value of 2 nM. Besides a low efflux in vitro, GNE 317 demonstrated pathway inhibition in normal brain tissue, inhibition of tumor growth in the U87 model of glioblastoma, and good potency in a panel of GBM cell lines.
More Information
| Parent CAS No. | 1394076-92-6 |
|---|---|
| Chemical Name | 5-(6-(3-Methoxyoxetan-3-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-2-yl)pyrimidin-2-amine |
| SMILES | C12SC(C3(OC)COC3)=C(C)C=1N=C(C1C=NC(N)=NC=1)N=C2N1CCOCC1 |
| MFCD | N.A. |
| InChi | InChI=1S/C19H22N6O3S/c1-11-13-14(29-15(11)19(26-2)9-28-10-19)17(25-3-5-27-6-4-25)24-16(23-13)12-7-21-18(20)22-8-12/h7-8H,3-6,9-10H2,1-2H3,(H2,20,21,22) |
| InChiKey | XOZLHJMDLKDZAL-UHFFFAOYSA-N |
| CID | 70676303 |
| Short Description | PI3K inhibitor |
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