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Axon 2994
CAS [1394076-92-6]
MF C19H22N6O3SMW 414.48
GNE 317 is a brain-penetrant PI3K α-isoform inhibitor with a Ki value of 2 nM. Besides a low efflux in vitro, GNE 317 demonstrated pathway inhibition in normal brain tissue, inhibition of tumor growth in the U87 model of glioblastoma, and good potency in a panel of GBM cell lines.
KEYWORDS: GNE 317 | supplier | PI3K inhibitor | GNE317 | GNE-317 | CAS [1394076-92-6] | Phosphatidylinositol | PI3K | Inhibitor | Enzymes | Brain-penetrant | Glioblastoma | GBM cells
5-(6-(3-Methoxyoxetan-3-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-2-yl)pyrimidin-2-amine
[1394076-92-6]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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