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UCL-TRO-1938
Axon 4019
CAS:
2919575-27-0
Purity:
98%
- Soluble in DMSO
- MF: C27H32N6O
- MW: 456.58
Description
UCL-TRO-1938 is a selective allosteric activator of PI3Kα with an EC50 value of ~60 μM (assessed by in vitro lipid kinase activity). The EC50 values on cells are shown to be 2-4 μM and 5 μM to stimulate downstream AKT phosphorylation and increase PIP3, respectively. In MEF cells, UCL-TRO-1938 shows an EC50 of 0.5 μM to increase ATP levels over 24 h. UCL-TRO-1938 transiently activates PI3K signalling in all rodent and human cells tested, resulting in cellular responses such as proliferation and neurite outgrowth. In rodent models, acute treatment with UCL-TRO-1938 provides cardioprotection from ischaemia reperfusion injury and, upon local administration, enhances nerve regeneration following nerve crush.
More Information
| Parent CAS No. | 2919575-27-0 |
|---|---|
| Chemical Name | 1-(7-(2-(4-(4-Ethylpiperazin-1-yl)phenylamino)pyridin-4-ylamino)indolin-1-yl)ethanone |
| MFCD | N.A. |
| Short Description | PI3Kα activator |
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