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WS-383 - DCN1-UBC12 interaction inhibitor E31

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 2984

CAS [2247543-65-1]

MF C18H20ClN9S2
MW 461.99

  • Purity: 99%
  • Soluble in DMSO

WS-383

Description

WS-383 effectively blocks interaction between DCN1 and UBC12 (IC50 value of 11 nM), causes selective Cul3/1 neddylation inhibition over other cullins, and induces accumulation of p21, p27, and NRF2.

KEYWORDS: WS-383 | supplier | DCN1-UBC12 inhibitor | DCN1-UBC12 interaction inhibitor E31 | WS383 | WS 383 | CAS [2247543-65-1] | [2247544-02-9] | Non Selective (Ubiquitin peptides) | Ubiquitin-conjugating enzyme (E2) | Inhibitor | Enzymes | UBE2M | UBC12 | DCN1 | NEDD8 | CRL

Highly potent, selective, and cellular active inhibitor of DCN1-UBC12 protein-protein interaction

Chemical name

2-(5-(2-(4-Chlorobenzylthio)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-ylthio)-1H-tetrazol-1-yl)-N,N-dimethylethanamine

Parent CAS No.

[2247543-65-1]

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5 mg €125.00 In Stock
25 mg €435.00 In Stock
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2 x 5 mg €200.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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