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JNK inhibitor VIII
- JNK inhibitor compound 6o
- Soluble in DMSO
- MF: C18H20N4O4
- MW: 356.38
Description
JNK inhibitor VIII is a selective, ATP-competitive, and cell-permeable JNK inhibitor with Ki values of 2 nM, 4 nM, and 52 nM for JNK1, JNK2, JNK3, respectively.
More Information
| Parent CAS No. | 894804-07-0 |
|---|---|
| Chemical Name | N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide |
| SMILES | C1C(N)=C(C#N)C(OCC)=NC=1NC(=O)CC1C(OC)=CC=C(OC)C=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C18H20N4O4/c1-4-26-18-13(10-19)14(20)9-16(22-18)21-17(23)8-11-7-12(24-2)5-6-15(11)25-3/h5-7,9H,4,8H2,1-3H3,(H3,20,21,22,23) |
| InChiKey | KQMPRSZTUSSXND-UHFFFAOYSA-N |
| CID | 11624601 |
| Short Description | JNK inhibitor |
References
- BG Szczepankiewicz et al. Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J Med Chem. 2006 Jun 15;49(12):3563-80.
- A Kauskot et al. Involvement of the mitogen-activated protein kinase c-Jun NH2-terminal kinase 1 in thrombus formation. J Biol Chem. 2007 Nov 2;282(44):31990-9.
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