Cambinol - NSC 112546

Based on 25 reference(s) in Google Scholar 8 10 25

Axon 2803

CAS [14513-15-6]

MF C21H16N2O2S
MW 360.43

  • Purity: 99%
  • Soluble in DMSO



Cambinol inhibits NAD-dependent deacetylase activity of human SIRT1 and SIRT2 (IC50 values of 56 and 59 μM, respectively). Consistent with the role of SIRT1 in promoting cell survival during stress, inhibition of SIRT1 activity with cambinol during genotoxic stress leads to hyperacetylation of key stress response proteins and promotes cell cycle arrest. Cambinol exerts antitumor activity in vitro and in mouse xenograft studies. Moreover, cambinol is an uncompetitive nSMase2 inhibitor (Ki value of 7 μM).

KEYWORDS: Cambinol | supplier | SIRT inhibitor | NSC 112546 | NSC112546 | NSC-112546 | CAS [14513-15-6] | Histone | SIRT | Inhibitor | Enzymes | nSMase2

Size Unit Price Stock
5 mg €95.00 In Stock
25 mg €285.00 In Stock
Special Offers
Size Unit Price Stock
2 x 5 mg €140.00 In Stock
2 x 25 mg €420.00 In Stock
Need more? Bulk Inquiry

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Please wait...