Microtubule inhibitor that binds to the colchicine-binding site of tubulin and suppresses JAK2/STAT3 signaling pathway through modulation of SOCS3 stability. MPT0B098 arrests cells in the G2-M phase and subsequently induces cell apoptosis. In addition, MPT0B098 effectively suppresses VEGF-induced cell migration and capillary-like tube formation of HUVECs. MPT0B098 not only inhibited the expression levels of HIF-1α protein but also destabilized HIF-1α mRNA.
KEYWORDS: MPT0B098 | supplier | Microtubule inhibitor | CAS [1254363-89-7] | Cytoskeleton | Tubulin | Inhibitor | colchicine | JAK2/STAT3 | SOCS3 | cell arrest | G2-M | apoptosis | cell migration | HIF-1α