IWR-1-endo - IWR-1 | endo-IWR-1

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2510

CAS [1127442-82-3]

MF C25H19N3O3
MW 409.44

  • Purity: 99%
  • Soluble in DMSO

IWR-1-endo

Description

Small-molecule inhibitor of the Wnt/β-catenin pathway (IC50 value 0.18 μM), strongly inhibiting TNKS1 and TNKS2 in biochemical assays, and targeting the acyltransferase Porcupine (Porcn) without inducing Porcn destruction or mislocalization. IWR-1-endo significantly stabilized endogenous TNKS1, TNKS2 and axin 2 by inhibition of auto-PARsylation of TNKS in vivo and independent of the PARsylation activity of PARP1/2. Furthermore, IWR-1 increased expression of genes commonly expressed in cardiac mesoderm/progenitor cell and significantly improved cardiac differentiation when introduced after the application of BMP-4.

KEYWORDS: IWR-1-endo | Supplier | Wnt/TNKS inhibitor | IWR-1 | IWR1 | CAS [1127442-82-3] | DNA-RNA | TNKS1 | TNKS2 | Tankyrase | Inhibitor | catenin | parp | parsylation | axin | cardiac | differentiation | Porcupine | Porcn

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10 mg €85.00 In Stock
50 mg €305.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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