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JZP 361
- Soluble in DMSO
- MF: C22H20ClN5O
- MW: 405.88
Description
JZP 361 is a potent and reversible inhibitor of monoacylglycerol lipase (MAGL) with additional histamine H1 receptor antagonist pharmacology. It elevates 2-arachidonoylglycerol signaling by limiting MAGL-dependent endocannabinoid hydrolysis.
MAGL regulates endocannabinoid tone and arachidonic acid production, linking cannabinoid signaling to neuroinflammation, pain and lipid mediator biology. JZP 361 is useful for studying reversible MAGL inhibition and dual MAGL/H1 pharmacology.
Key Features
- Potent and reversible MAGL inhibitor
- Reported IC50: 46 nM for MAGL
- Selectivity reported over ABHD6 and FAAH
- Also displays histamine H1 receptor antagonist activity
Applications
- Endocannabinoid metabolism research
- MAGL inhibitor pharmacology
- Pain and neuroinflammation pathway studies
- Dual lipid enzyme/GPCR profiling assays
More Information
| Parent CAS No. | 1680193-80-9 |
|---|---|
| Chemical Name | [4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinyl]-1H-1,2,4-triazol-1-yl-methanone |
| SMILES | C(N1CC/C(=C2/C3=NC=CC=C3CCC3=CC(Cl)=CC=C3/2)/CC1)(N1C=NC=N1)=O |
| MFCD | N.A. |
| InChi | InChI=1S/C22H20ClN5O/c23-18-5-6-19-17(12-18)4-3-16-2-1-9-25-21(16)20(19)15-7-10-27(11-8-15)22(29)28-14-24-13-26-28/h1-2,5-6,9,12-14H,3-4,7-8,10-11H2 |
| InChiKey | GAVZCGTYRWKKDV-UHFFFAOYSA-N |
| CID | 102596130 |
| Short Description | MAGL inhibitor/H1 antagonist |
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