Gö 6983 - GO 6983 | Goe 6983

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2466

CAS [133053-19-7]

MF C26H26N4O3
MW 442.51

  • Purity: 99%
  • Soluble in DMSO

Gö 6983

Description

Broad spectrum PKC inhibitor lacking inhibitory effect for the PKCμ isotype (IC50 values ranging from 7-60 nM for PKCα-PKCζ , and 20000 nM for PKCμ, respectively). Gö6983 significantly enhanced ERK1/2 activity not only in IL-6-stimulated cells, but also the basal ERK1/2 activity in non-stimulated cells; yet, it has no effect on IL-6-triggered B9 cell proliferation, suggesting a crucial role for PKCμ. Useful tool for isolation, generation, derivatization and stabilization of naive human pluripotent stem cells in so called NHSM conditions developed at the Weizmann Institute of Science.

*Promotion: Gö 6983 is also part of Inhibitor Set(s):

Axon 5010


KEYWORDS: GO 6983 | supplier | PKC inhibitor | GO6983 |  6983 | Gö6983 | GO6983 | CAS [133053-19-7] | PKCμ | Inhibitor | MAPK | ERK | ischemia | reperfusion | IL-6 | proliferation  | naïve | pluripotent | stem cells 

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5 mg €90.00 In Stock
25 mg €315.00 In Stock
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2 x 5 mg €140.00 In Stock
2 x 25 mg €500.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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