(26 publications from 2018 to 2025 as examples; incomplete list)

 

Van Nerum, K., Wenzel, A., Argemi-Muntadas, L., Kafkia, E., Drews, A., Brun, I. S., ... & Żylicz, J. J. (2025). α-Ketoglutarate promotes trophectoderm induction and maturation from naive human embryonic stem cells. Nature Cell Biology, 1-13.

* PD0325901 + CHIR99021 + GO6983 + Y27632 + A8301 + SB431542 + valproic acid etc from Axon Medchem

 

Rossignoli, G., Oberhuemer, M., Brun, I. S., Zorzan, I., Osnato, A., Wenzel, A., ... & Martello, G. (2025). Feeder-free culture of naive human pluripotent stem cells retaining embryonic, extraembryonic and blastoid generation potential. bioRxiv, 2025-01.

* PD0325901, XAV939, GO6983, Y27632, CHIR99021, A83-01, SB431542, PD173174, ec from Axon Medchem

 

Arboit, M., Zorzan, I., Pensabene, E., Pellegrini, M., Bertelli, F., Panebianco, G., ... & Martello, G. (2025). KLF7 is a general inducer of human pluripotency. EMBO reports, 26(22), 5372.

* PD0325901, CHIR99021, XAV939, GO6983, Y27632, CHIR99021, A83-01, SB432542, etc from Axon Medchem

 

Onfray, C., Chevolleau, S., Moinard, E., Girard, O., Mahadik, K., Allsop, R., ... & David, L. (2024). Unraveling hallmark suitability for staging pre-and post-implantation stem cell models. Cell Reports, 43(5).

* CHIR99021, PD0325901, Y27632, A83-01, SB431542, GO6983, XAV927, IWR-1-endo from Axon Medchem

 

Levin-Ferreyra, F., Kodali, S., Cui, Y., Pashos, A. R., Pessina, P., Brumbaugh, J., & Di Stefano, B. (2024). Transposable element activity captures human pluripotent cell states. EMBO reports, 26(2), 329.

*7i: Y27632, IM-12, SB590885, WH-4-023, PD0325901, XAV939, GO6983 from Axon Medchem

 

Żylicz, J., van Nerum, K., Wenzel, A., Muntadas, L. A., Kafkia, E., Lavro, V., ... & Moritz, T. (2024). Metabolic rewiring underpins human trophoblast induction. Preprint at https://doi. org/10.21203/rs, 3.

* CHIR99021, PD0325901, Y27632, GO6983, XAV939,

 

Arboit, M., Zorzan, I., Pellegrini, M., Martini, P., Carbognin, E., & Martello, G. (2023). KLF7 is a general inducer of human pluripotency. bioRxiv, 2023-09.

*7i: PD0325901, Y27632, XAV939, GO6983, CHIR99021, A83-01, SB432541 from Axon Medchem

 

Oldak, B., Wildschutz, E., Bondarenko, V., Comar, M. Y., Zhao, C., Aguilera-Castrejon, A., ... & Hanna, J. H. (2023). Complete human day 14 post-implantation embryo models from naive ES cells. Nature, 622(7983), 562-573.

https://www.nature.com/articles/s41586-023-06604-5.

*7i from Axon Medchem, incl GO6983, PD0325901, CGP77675, Y27632, BIR796, A83-01, CHIR99021.

 

Etxaniz Díaz de Durana, J. (2023). A Comparative Study Of Cell Culture Conditions During Conversion From Primed To Naive Human Pluripotent Stem Cells.

CHIR99021, PD0325901, SP600125, BIRB796, Y27632, GO6983 from Axon Medchem

 

Zorzan, I., Betto, R. M., Rossignoli, G., Arboit, M., Drusin, A., Corridori, C., ... & Martello, G. (2023). Chemical conversion of human conventional PSCs to TSCs following transient naive gene activation. EMBO reports, 24(4), e55235.

* PD0325901, XAV939, GO6983, Y27632, CHIR99021, A83-01 and SB431542 from Axon Medchem

 

Castel, G., & David, L. (2022). Induction of human trophoblast stem cells. Nature protocols, 17(12), 2760-2783.

* Y27632, CHIR99021, A83-01, SB431542, PD0325901, GO6983, IWR-endo-1, Foskolin from Axon Medchem

 

Romayor, I., Herrera, L., Burón, M., Martin-Inaraja, M., Prieto, L., Etxaniz, J., ... & Eguizabal, C. (2022). A Comparative Study of Cell Culture Conditions during Conversion from Primed to Naive Human Pluripotent Stem Cells. Biomedicines, 10(6), 1358.

* CHIR99021, PD0325901, Y27632, Go6983, SP600125 and BIRB796 from Axon Medchem

 

Zorzan, I., Betto, R. M., Rossignoli, G., Arboit, M., Drusin, A., Martini, P., & Martello, G. (2022). Chemical conversion of human conventional Pluripotent Stem Cells to Trophoblast Stem Cells. bioRxiv, 2022-04.

*PD0325901, XAV939, Go6983, Y27632, CHIR99021, A83-01, SB431542 from Axon Medchem

 

Viukov, S., Shani, T., Bayerl, J., Sheban, D., Stelzer, Y., Novershtern, N., & Hanna, J. H. (2022). Human primed and naïve PSCs are both competent in differentiating into bona fide trophoblast stem cells. BioRxiv, 2022-05.

*PD0325901, XAV939, GO6983, CGP77675, BIRB796, A883-01, CHIR99021, Y27632 from Axon Medchem

 

Viukov, S., Shani, T., Bayerl, J., Aguilera-Castrejon, A., Oldak, B., Sheban, D., ... & Novershtern, N. (2022). Human primed and naïve PSCs are both able to differentiate into trophoblast stem cells. Stem cell reports, 17(11), 2484-2500.

* PD0325901, XAV939, Go6983,Y27632, CGP77675, PD173074 and CHIR99021 from Axon Medchem

 

Girard, O., Lavigne, R., Chevolleau, S., Onfray, C., Com, E., Schmit, P. O., ... & Pineau, C. (2022). Naive Pluripotent and Trophoblastic Stem Cell Lines as a Model for Detecting Missing Proteins in the Context of the Chromosome-Centric Human Proteome Project. Journal of Proteome Research, 22(4), 1148-1158.

* PD0325901, XAV939, GO6983, Y27632 and CHIR99021 from Axon Medchem

 

Bayerl, J., Ayyash, M., Shani, T., Manor, Y. S., Gafni, O., Massarwa, R., ... & Hanna, J. H. (2021). Principles of signaling pathway modulation for enhancing human naive pluripotency induction. Cell Stem Cell. 28(9), 1549-1565.

* CHIR99021 and 14i from Axon Medchem (including PD0325901, IWR1, BIR0796, Go6983, Y27632, CGP77675, RIN1, LDN193189, A83-01, SB590885, BIX02189, RU-SKI43, BIX01294.

 

Bayerl, J., Ayyash, M., Shani, T., Manor, Y., Gafni, O., Kalma, Y., ... & Hanna, J. H. (2020). Tripartite Inhibition of SRC-WNT-PKC Signalling Consolidates Human Naïve Pluripotency. bioRxiv.

* CHIR99021, PD 0325901, IWR-1, XAV 939, BIRB0796, Go6983, Y27632, CGP77675, LDN193189, A83-01, DBZ, SB590885, BIX02189, RU-SKI43, BIX-02194

 

Castel, G., Meistermann, D., Bretin, B., Firmin, J., Blin, J., Loubersac, S., ... & David, L. (2020). Induction of Human Trophoblast Stem Cells from Somatic Cells and Pluripotent Stem Cells. Cell Reports, 33(8), 108419.

* 8 inhibitors are from Axon Medchem, including CHIR99021, PD0325901, Y27632, IWR-1, A83-01, SB431542, Go6983, Forskolin.

 

Castel, G., Meistermann, D., Bretin, B., Firmin, J., Justine, B. L. I. N., Loubersac, S., ... & David, L. (2020). Generation of human induced trophoblast stem cells. bioRxiv.

*Y27632, CHIR99021, PD0325901, GO6983 and PD173074 etc from Axon Medchem

 

Giulitti, S., Pellegrini, M., Zorzan, I., Martini, P., Gagliano, O., Mutarelli, M., ... & Martello, G. (2019). Direct generation of human naive induced pluripotent stem cells from somatic cells in microfluidics. Nat. Cell Biol, 21, 1-19.

*6i: CHIR99021, PD0325901, GO6983, WH-4-023, SB590885, and Y27632 from Axon Medchem

 

Canizo, J. R., Rivolta, A. E. Y., Echegaray, C. V., Suvá, M., Alberio, V., Aller, J. F., ... & Alberio, R. (2019). A dose-dependent response to MEK inhibition determines hypoblast fate in bovine embryos. BMC developmental biology, 19(1), 13.

* PD0325901, GO6983 from Axon Medchem

 

Giulitti, S., Pellegrini, M., Zorzan, I., Martini, P., Gagliano, O., Mutarelli, M., ... & Martello, G. (2018). Direct generation of human naive induced pluripotent stem cells from somatic cells in microfluidics. Nature cell biology.

*6i: CHIR99021, PD0325901, GO6983, WH-4-023, SB590885, and Y27632 from Axon Medchem

 

Mor, N., Rais, Y., Sheban, D., Peles, S., Aguilera-Castrejon, A., Zviran, A., ... & Hanna J.H. (2018). Neutralizing Gatad2a-Chd4-Mbd3/NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency. Cell stem cell. 23 (3), 412-425.e10

*CHIR99021, PD0325901, GO6983, CPG77675, Y27632, DBZ from Axon Medchem

 

Sahakyan, A., Clement, K., Clowers, K. J., Erickson, A. R., Shioda, K., Gygi, S. P., ... & Hochedlinger. K. (2018) Reduced MEK inhibition preserves genomic stability in naive human embryonic stem cells. Nature Methods. 15, 732–740.

*CHIR99021, PD0325901, GO6983, Y27632, IM12, SB590885, WH4-023 .. from Axon Medchem

 

Di Stefano, B., & Hochedlinger, K. Reduced MEK inhibition preserves genomic stability in naïve human ES cells. Protocol Exchange, doi, 10. (2018)

* Y-27632, PD0325901, Gö6983, IM-12, SB590885, WH-4-023 and CHIR99021 from Axon Medchem