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LH 846
Axon 2297
CAS:
639052-78-1
Purity:
99%
- Soluble in DMSO
- MF: C16H13ClN2OS
- MW: 316.81
Description
Potent and selective inhibitor of CK1δ ( IC50 values of 2.5 mM, 290 nM, and 1.3 mM for CK1α, CK1δ, and CK1ε, respectively) that showed no inhibitory effect on CK2. LH 846 modulates circadian rhythms through phosphorylation of the period protein with a significant effect on circadian period length (10 h) with minimal effect on the amplitude of both Per2-dLuc and Bmal1-dLuc rhythms in U2OS cells.
More Information
| Parent CAS No. | 639052-78-1 |
|---|---|
| Chemical Name | N-(5-chloro-6-methylbenzo[d]thiazol-2-yl)-2-phenylacetamide |
| SMILES | C1(CC(NC2=NC3=CC(Cl)=C(C)C=C3S2)=O)=CC=CC=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C16H13ClN2OS/c1-10-7-14-13(9-12(10)17)18-16(21-14)19-15(20)8-11-5-3-2-4-6-11/h2-7,9H,8H2,1H3,(H,18,19,20) |
| InChiKey | DYHAMRNAHTWYKY-UHFFFAOYSA-N |
| CID | 851474 |
| Short Description | CK 1δ inhibitor |
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