AZD 2461

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2241

CAS [1174043-16-3]

MF C22H22FN3O3
MW 395.43

  • Purity: 99%
  • Soluble in DMSO

AZD 2461

Description

PARP inhibitor (IC50 value 5 nM) with poor P-glycoprotein substrate qualities. Unlike treatment with AZD 2281 (Olaparib, Axon 1464), AZD 2461 succesfully circumvents drug resistance of Pgp-proficient tumors, and inactivation of p53-binding protein 1 (53BP1) as a causal factor in PARPi resistance.

KEYWORDS: AZD 2461 | supplier | PARP inhibitor | AZD2461 | AZD-2461 | CAS [1174043-16-3] | DNA-RNA | PARP1 | P-gp | AZD 2281 | Olaparib | drug resistance | tumors | p53 | binding protein 1 | 53BP1 | PARPi | resistance

Order
Size Unit Price Stock
10 mg €105.00 In Stock
50 mg €345.00 In Stock
Special Offers
Size Unit Price Stock
2 x 10 mg €160.00 In Stock
2 x 50 mg €540.00 In Stock
Need more? Bulk Inquiry

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Please wait...