SSR 128129E

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2234

CAS [848318-25-2]

MF C18H15N2NaO4
MW 346.31

  • Purity: 99%
  • Soluble in water and DMSO

SSR 128129E


Extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling with oral bioavailability. SSR 128129E inhibits responses mediated by FGFR1-4 (IC50 values 15-28 nM for FGF2 induced FGFR stimulation), but not by other related RTKs.SSR 128129E does not inhibit all FGFR signaling pathways indiscriminatively but selectively blocks particular signaling pathways, dependent on the cellular context. Capable of inhibiting angiogenesis, inflammation, and bone resorption in arthritis, and delays tumor growth and metastasis.
Size Unit Price Stock
10 mg €110.00 In Stock
50 mg €370.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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