LY 2811376

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2225

CAS [1194044-20-6]

MF C15H14F2N4S
MW 320.36

  • Purity: 99%
  • Soluble in 0.1N HCl(aq), DMSO, and Ethanol

LY 2811376

Description

The first orally available non-peptidic BACE1 inhibitor (IC50 value ranges from 239-249 nM in vitro) that produces profound Aβ-lowering effects in animals. LY2811376 demonstrated ~10-fold selectivity toward BACE1 over BACE2, and >50-fold selectivity over cathepsin D, pepsin, or renin. Clinical development of LY 2811376 was terminated as a result of toxicology findings identified in longer-term preclinical studies.
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5 mg €125.00 In Stock
25 mg €425.00 In Stock
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2 x 5 mg €200.00 In Stock
2 x 25 mg €700.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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