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Verubecestat
- MK8931
Axon 4166
CAS:
1286770-55-5
- Optical Purity: Optically pure
- Soluble in DMSO and EtOH
- MF: C17H17F2N5O3S
- MW: 409.41
Description
Verubecestat is a first-in-class, potent, orally bioavailable high-affinity BACE1 inhibitor with Ki values of 2.2 and 0.38 nM for BACE1 and BACE2, respectively. Verubecestat shows high selectivity for BACE1 over other key aspartyl proteases.
More Information
| Parent CAS No. | 1286770-55-5 |
|---|---|
| Chemical Name | N-[3-[(5R)-3-amino-2,5-dimethyl-1,1-dioxo-6H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-fluoropyridine-2-carboxamide |
| SMILES | C1(F)C=NC(C(=O)NC2C=C([C@@]3(C)NC(=N)N(C)S(=O)(=O)C3)C(F)=CC=2)=CC=1 |&1:11,r| |
| MFCD | N.A. |
| InChi | N.A. |
| InChiKey | N.A. |
| CID | N.A. |
| Short Description | BACE 1 inhibitor |
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