Lomeguatrib - PaTrin 2

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2223

CAS [192441-08-0]

MW 326.17

  • Purity: 99%
  • Soluble in DMSO



Potent, orally active inhibitor of O6-methylguanine-DNA-methyltransferase (MGMT; IC50 value 5 nM). Lomeguatrib effectively inactivated MGMT in MCF-7 cells and in xenografts there was complete inactivation of MGMT within 2 h of dosing (20 mg/kg i.p.) and only slight recovery by 24 h.Oral administration of Lomeguatrib substantially increases the haematological toxicity of Dacarbazine, the only approved chemotherapeutic agent for the treatment of metastatic melanoma. In combination with Temozolomide, Lomeguatrib produced a substantial tumour growth delay in MCF-7 xenografts.
Size Unit Price Stock
10 mg €135.00 In Stock
50 mg €475.00 In Stock
Special Offers
Size Unit Price Stock
2 x 10 mg €220.00 In Stock
2 x 50 mg €800.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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