Genz 644282

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2198

CAS [529488-28-6]

MF C22H21N3O5
MW 407.42

  • Purity: 99%
  • Soluble in 0.1N HCl(aq) and DMSO

Genz 644282


Topoisomerase I inhibitor (IC50 value 0.4 nM in human bone marrow CFU-GM assay). Cytotoxic agent, with activity toward 8 human tumor cell lines of varied histology and resistance mechanisms by colony formation, with enhanced potency compared to topotecan and SN-38. Contrary to the camptothecins, Genz-644282 is not a substrate for the multidrug resistance gene 1 (MDR1) and breast cancer resistance protein (BCRP) efflux pumps.
Size Unit Price Stock
5 mg €95.00 In Stock
25 mg €315.00 In Stock
Special Offers
Size Unit Price Stock
2 x 5 mg €140.00 In Stock
2 x 25 mg €460.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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