FQI 1

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2157

CAS [599151-35-6]

MF C18H17NO4
MW 311.33

Purity: 99%
Soluble in DMSO

FQI 1

Description

Antiproliferative small-molecule inhibitor of α-globin transcription factor CP2 (a.k.a. LSF; IC50 2.1 μM); cell-permeable, potent, specific, and reversible. FQI 1 induces cell death in LSF-overexpressing cells, including Hepatocellular carcinoma (HCC cells). FQI 1 inhibits LSF DNA-binding activity both in vitro and in vivo and also inhibits HCC tumor growth in a mouse xenograft model.

T.J. Granta et al. Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma. PNAS 2012, 109, 4503–4508.

H.C. Kang et al. Erythroid Cell-Specific α-Globin Gene Regulation by the CP2 Transcription Factor Family. Mol. Cell. Biol. 2005, 25, 6005–6020.

Cell Cycle Regulation Cell Signaling & Oncology CNS Immunology Pain & Inflammation CP2 Transcription Factors TF class 4

Inhibitor of α-globin transcription factor CP2 (LSF)

Chemical name

8-(2-ethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]quinolin-6(5H)-one

Parent CAS No.

[599151-35-6]

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