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PF 04447943
- PF 4447943
- Optical Purity: Optically pure
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C20H25N7O2
- MW: 395.46
Description
More Information
| Parent CAS No. | 1082744-20-4 |
|---|---|
| Chemical Name | 6-((3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one |
| SMILES | C1([C@H]2[C@H](C)CN(CC3=NC=CC=N3)C2)NC(=O)C2C=NN(C3CCOCC3)C=2N=1 |&1:1,2,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C20H25N7O2/c1-13-10-26(12-17-21-5-2-6-22-17)11-16(13)18-24-19-15(20(28)25-18)9-23-27(19)14-3-7-29-8-4-14/h2,5-6,9,13-14,16H,3-4,7-8,10-12H2,1H3,(H,24,25,28)/t13-,16-/m1/s1 |
| InChiKey | IWXUVYOOUMLUTQ-CZUORRHYSA-N |
| CID | 135564558 |
| Short Description | PDE9A inhibitor |
References
- P.R. Verhoest et al. Design and discovery of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943),..... J. Med. Chem. 2012, 55, 9045-9054.
- M.M. Claffey et al. Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors. J. Med. Chem. 2012, 55, 9055-9068.
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