PF 04447943 - PF 4447943

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2148

CAS [1082744-20-4]

MF C20H25N7O2
MW 395.46

Purity: 99%
Optical purity: Optically pure
Soluble in 0.1N HCl(aq) and DMSO

PF 04447943

Description

Selective, brain penetrant PDE9A inhibitor for the treatment of cognitive disorders that exhibit a disrupted P50-gating response (IC50 values 8.3 nM and 1394 nM for PDE9A and PDE1C respectively). PF 04447943 elevates cGMP in multiple brain regions and in cerebral spinal fluid (CSF), and shows an impact on hippocampal synaptic plasticity.

P.R. Verhoest et al. Design and discovery of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943),..... J. Med. Chem. 2012, 55, 9045-9054.

M.M. Claffey et al. Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors. J. Med. Chem. 2012, 55, 9055-9068.

Selective, brain penetrant PDE9A inhibitor

Chemical name

6-((3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one

Parent CAS No.

[1082744-20-4]

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Size	Unit Price	Stock
2 mg	€70.00	In Stock
5 mg	€120.00	In Stock
25 mg	€420.00	In Stock

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PF 04447943 - PF 4447943

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PF 04447943 - PF 4447943

Description

Chemical name

Parent CAS No.

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