PF 04447943 - PF 4447943

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2148

CAS [1082744-20-4]

MF C20H25N7O2
MW 395.46

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in 0.1N HCl(aq) and DMSO

PF 04447943

Description

Selective, brain penetrant PDE9A inhibitor for the treatment of cognitive disorders that exhibit a disrupted P50-gating response (IC50 values 8.3 nM and 1394 nM for PDE9A and PDE1C respectively). PF 04447943 elevates cGMP in multiple brain regions and in cerebral spinal fluid (CSF), and shows an impact on hippocampal synaptic plasticity.
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Size Unit Price Stock
2 mg €115.00 In Stock
5 mg €185.00 In Stock
25 mg €575.00 In Stock
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Size Unit Price Stock
2 x 5 mg €270.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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