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Carbazeran
- UK31557
- Soluble in 0.1N HCl(aq), DMSO and EtOH
- MF: C18H24N4O4
- MW: 360.41
Description
Carbazeran is a potent phosphodiesterase inhibitor and an aldehyde oxidase (AO) substrate. Carbazeran produced positive inotropic responses in rabbit isolated heart preparations that were associated with increases in intracellular cyclic AMP and cyclic GMP concentrations.
More Information
| Parent CAS No. | 70724-25-3 |
|---|---|
| Chemical Name | 1-(6,7-Dimethoxyphthalazin-1-yl)piperidin-4-yl ethylcarbamate |
| SMILES | C1(OC)C=C2C(N3CCC(OC(=O)NCC)CC3)=NN=CC2=CC=1OC |
| MFCD | MFCD00867107 |
| InChi | InChI=1S/C18H24N4O4/c1-4-19-18(23)26-13-5-7-22(8-6-13)17-14-10-16(25-3)15(24-2)9-12(14)11-20-21-17/h9-11,13H,4-8H2,1-3H3,(H,19,23) |
| InChiKey | QJGVXJYGDBSPSJ-UHFFFAOYSA-N |
| CID | 71983 |
| Short Description | PDE inhibitor |
References
- M Shahid et al. Chronotropic and inotropic actions of amrinone, carbazeran and isobutylmethyl xanthine: role of phosphodiesterase inhibition. Br J Pharmacol. 1989 Sep;98(1):291-301.
- S Uehara et al. Human Aldehyde Oxidase 1-Mediated Carbazeran Oxidation in Chimeric TK-NOG Mice Transplanted with Human Hepatocytes. Drug Metab Dispos. 2020 Jul;48(7):580-586.
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