Bulk Inquiry
GW4869 trifluoroacetate
- GW554869 TFA
- Parent CAS: 475570-61-7
- Soluble in DMSO
- MF: C30H28N6O2.2C2HF3O2
- MW: 732.63
Description
GW4869 is a noncompetitive inhibitor of neutral, magnesium-dependent sphingomyelinase (N-SMase) with an IC50 value of 1 μM. GW4869 did not inhibit acid SMase at up to at least 150 μM.
*GW4869 is poorly soluble in DMSO and other common solvents. GW4869 is usually formulated as a suspension. GW4869 (TFA) has a better solubility and bioavailability than GW4869 (HCl).
More Information
| Parent CAS No. | 475570-61-7 |
|---|---|
| Chemical Name | 3-[4-[3-[4-(4,5-Dihydro-1H-imidazol-2-yl)anilino]-3-oxoprop-1-enyl]phenyl]-N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]prop-2-enamide trifluoroacetate |
| SMILES | C1C(NC(=O)/C=C/C2C=CC(/C=C/C(=O)NC3C=CC(C4NCCN=4)=CC=3)=CC=2)=CC=C(C2NCCN=2)C=1.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O |
| MFCD | N.A. |
| InChi | InChI=1S/C30H28N6O2.2C2HF3O2/c37-27(35-25-11-7-23(8-12-25)29-31-17-18-32-29)15-5-21-1-2-22(4-3-21)6-16-28(38)36-26-13-9-24(10-14-26)30-33-19-20-34-30;2*3-2(4,5)1(6)7/h1-16H,17-20H2,(H,31,32)(H,33,34)(H,35,37)(H,36,38);2*(H,6,7)/b15-5+,16-6+;; |
| InChiKey | OVUGNZQTDFNYTB-CLEIDKRQSA-N |
| CID | 155903167 |
| Short Description | N-SMase inhibitor |
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