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PDE9A inhibitor C33(S)
- (S)-C33
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C18H20ClN5O
- MW: 357.84
Description
(S)-C33 is a potent and selective PDE9A inhibitor with an IC50 value of 11 nM.
More Information
| Parent CAS No. | 2066488-39-7 |
|---|---|
| Chemical Name | (S)-6-(1-(4-Chlorophenyl)ethylamino)-1-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-4(7H)-one |
| SMILES | C[C@H](NC1=NC2N(N=CC=2C(=O)N1)C1CCCC1)C1C=CC(Cl)=CC=1 |&1:1,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C18H20ClN5O/c1-11(12-6-8-13(19)9-7-12)21-18-22-16-15(17(25)23-18)10-20-24(16)14-4-2-3-5-14/h6-11,14H,2-5H2,1H3,(H2,21,22,23,25)/t11-/m0/s1 |
| InChiKey | FIUCLBJMUGCQTF-NSHDSACASA-N |
| CID | 135567003 |
| Short Description | PDE9A inhibitor |
References
- M Huang et al. Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor. Mol Pharmacol. 2015 Nov;88(5):836-45.
- PX Wang et al. C33(S), a novel PDE9A inhibitor, protects against rat cardiac hypertrophy through upregulating cGMP signaling. Acta Pharmacol Sin. 2017 Sep;38(9):1257-1268.
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