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GLPG1690
- Ziritaxestat
- Soluble in DMSO
- MF: C30H33FN8O2S
- MW: 588.7
Description
GLPG1690 is a first-in-class, potent autotaxin (ATX) inhibitor with a Ki value of 15 nM. GLPG1690 demonstrated significant activity in the mouse BLM-induced fibrosis model at doses of 10 and 30 mg/kg twice a day, with an efficacy comparable or superior to that of the reference compound pirfenidone.
More Information
| Parent CAS No. | 1628260-79-6 |
|---|---|
| Chemical Name | 2-((2-Ethyl-6-(4-(2-(3-hydroxyazetidin-1-yl)-2-oxoethyl)piperazin-1-yl)-8-methylimidazo[1,2-a]pyridin-3-yl)(methyl)amino)-4-(4-fluorophenyl)thiazole-5-carbonitrile |
| SMILES | C1(N2CCN(CC(N3CC(O)C3)=O)CC2)=CN2C(N(C)C3=NC(C4C=CC(F)=CC=4)=C(C#N)S3)=C(CC)N=C2C(C)=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C30H33FN8O2S/c1-4-24-29(35(3)30-34-27(25(14-32)42-30)20-5-7-21(31)8-6-20)39-15-22(13-19(2)28(39)33-24)37-11-9-36(10-12-37)18-26(41)38-16-23(40)17-38/h5-8,13,15,23,40H,4,9-12,16-18H2,1-3H3 |
| InChiKey | REQQVBGILUTQNN-UHFFFAOYSA-N |
| CID | 90420193 |
| Short Description | ATX inhibitor |
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