TAK 700 - Orteronel

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2124

CAS [566939-85-3]

MF C18H17N3O2
MW 307.35

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in DMSO

TAK 700


Potent, orally available, and highly selective inhibitor of 17,20-lyase (CYP17A1; IC50 value 19 nM and 48 nM for human and rat respectively) and of correlated androgen synthesis. TAK 700 exhibits no affinity for CYP11B 1and CYP3A4 (IC50 values >1000 nM and >10000 nM resp.), nor for other isoforms of the human CYP enzyme (IC50 values >14000 nM). When given orally to monkeys at a dose of 1 mg/kg, TAK 700 markedly reduced serum testosterone and DHEA at 5 h after administration. TAK 700 was selected for evaluation in patients in phase III clinical trials for the potential treatment of prostate cancer.
Size Unit Price Stock
5 mg €105.00 In Stock
25 mg €360.00 In Stock
Special Offers
Size Unit Price Stock
2 x 5 mg €160.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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