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RU 58841
- Soluble in DMSO
- MF: C17H18F3N3O3
- MW: 369.34
Description
RU 58841 is a specific androgen receptor (AR) antagonist used to block androgen-dependent transcriptional signaling.
Androgen receptor activity regulates reproductive tissues, sebaceous biology, hair follicle signaling and hormone-dependent cancer pathways. RU 58841 is useful as a topical anti-androgen research tool in cellular and tissue models of androgen responsiveness.
Key Features
- Specific antagonist of androgen receptor signaling
- Blocks androgen-dependent transcriptional activity
- Useful for hair follicle and dermal papilla research
- Relevant to hormone-responsive tissue models
Applications
- Androgen receptor pharmacology
- Hair follicle biology and alopecia models
- Hormone-dependent cancer signaling studies
- Nuclear receptor antagonist assays
Research use only: This product is not intended or sold for diagnostic, therapeutic or self-administration use.
More Information
| Parent CAS No. | 154992-24-2 |
|---|---|
| Chemical Name | 4-(3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile |
| SMILES | N1(CCCCO)C(C)(C)C(=O)N(C2C=C(C(F)(F)F)C(C#N)=CC=2)C1=O |
| MFCD | MFCD00925776 |
| InChi | InChI=1S/C17H18F3N3O3/c1-16(2)14(25)23(15(26)22(16)7-3-4-8-24)12-6-5-11(10-21)13(9-12)17(18,19)20/h5-6,9,24H,3-4,7-8H2,1-2H3 |
| InChiKey | ARBYGDBJECGMGA-UHFFFAOYSA-N |
| CID | 132981 |
| Short Description | AR antagonist |
References
- N Obana et al. Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque. Endocrinology 1997, 138(1), 356-361.
- T Battmann et al. RU 58841, a new specific topical antiandrogen: A candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism. J. Steroid Biochem. Mol. Biol. 1994, 48(1), 55-60.
- HI Pan et al. Evaluation of RU58841 as an anti-androgen in prostate PC3 cells and a topical anti-alopecia agent in the bald scalp of stumptailed macaques. Endocrine 1998, 9(1) 39-43.
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