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Hydroxyflutamide
- Soluble in DMSO and EtOH
- MF: C11H11F3N2O4
- MW: 292.21
Description
Hydroxyflutamide, an active metabolite of flutamide, is a first-generation non-steroidal antiandrogen with an IC50 value of 700 nM.
More Information
| Parent CAS No. | 52806-53-8 |
|---|---|
| Chemical Name | N-(4-Nitro-3-(trifluoromethyl)phenyl)2-hydroxy-2-methylpropionamide |
| SMILES | C1=CC(NC(=O)C(O)(C)C)=CC(C(F)(F)F)=C1[N+]([O-])=O |
| MFCD | MFCD00563126 |
| InChi | InChI=1S/C11H11F3N2O4/c1-10(2,18)9(17)15-6-3-4-8(16(19)20)7(5-6)11(12,13)14/h3-5,18H,1-2H3,(H,15,17) |
| InChiKey | YPQLFJODEKMJEF-UHFFFAOYSA-N |
| CID | 91649 |
| Short Description | AR antagonist |
References
- HL Liu et al. A Molecular Modeling Study of the Hydroxyflutamide Resistance Mechanism Induced by Androgen Receptor Mutations. Int J Mol Sci. 2017 Aug 23;18(9):1823.
- CA Berrevoets et al. Antiandrogens: selective androgen receptor modulators. Mol Cell Endocrinol. 2002 Dec 30;198(1-2):97-103.
- BJ Furr et al. Casodex: preclinical studies and controversies. Ann N Y Acad Sci. 1995 Jun 12;761:79-96.
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