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SC912
- Soluble in DMSO
- MF: C22H13Cl2F3N4O2
- MW: 493.27
Description
SC912 is an AR-V7 inhibitor which binds to full-length AR as well as AR-V7 through AR N-terminal domain (AR-NTD). SC912 also disrupted AR-V7 transcriptional activity, impaired AR-V7 nuclear localization and DNA binding. In the AR-V7 positive CRPC cells, SC912 suppressed proliferation, induced cell-cycle arrest, and apoptosis. In the AR-V7 expressing CRPC xenografts, SC912 attenuated tumor growth and antagonized intratumoral AR signaling.
More Information
| Parent CAS No. | N.A. |
|---|---|
| Chemical Name | N-{2-[3-(3-Cyanophenyl)urea]-5-(trifluoromethyl)phenyl}-3,5-dichlorobenzamide |
| MFCD | N.A. |
| Short Description | AR-V7 inhibitor |
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