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Cyproterone acetate
- SH714
Axon 3883
CAS:
427-51-0
- Optical Purity: Optically pure
- Soluble in DMSO and EtOH
- MF: C24H29ClO4
- MW: 416.94
Description
Cyproterone acetate is an androgen receptor (AR) antagonist (IC50 value of 7.1 nM), but also being a partial AR agonist at relatively high concentrations (EC50 value of 4.0 μM).
More Information
| Parent CAS No. | 427-51-0 |
|---|---|
| Chemical Name | (2aR,3aS,3bS,5aS,6R)-6-Acetyl-10-chloro-3b,5a-dimethyl-2-oxo-2,2a,3,3a,3b,3c,4,5,5a,6,7,8,8a,8b-tetradecahydrocyclopenta[a]cyclopropa[g]phenanthren-6-yl acetate |
| SMILES | [C@@H]12C[C@@H]1[C@]1(C)C3CC[C@]4(C)[C@@](OC(C)=O)(C(=O)C)CCC4C3C=C(Cl)C1=CC2=O |&1:0,2,3,8,10,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C24H29ClO4/c1-12(26)24(29-13(2)27)8-6-16-14-10-20(25)19-11-21(28)15-9-18(15)23(19,4)17(14)5-7-22(16,24)3/h10-11,14-18H,5-9H2,1-4H3/t14?,15-,16?,17?,18+,22+,23+,24+/m1/s1 |
| InChiKey | UWFYSQMTEOIJJG-WMANOXGZSA-N |
| CID | 5702030 |
| Short Description | AR antagonist |
References
- E Sonneveld et al. Development of androgen- and estrogen-responsive bioassays, members of a panel of human cell line-based highly selective steroid-responsive bioassays. Toxicol Sci. 2005 Jan;83(1):136-48.
- DJ Tindall et al. Androgen antagonists in androgen target tissues. Pharmacol Ther. 1984;24(3):367-400.
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