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ARN 509
- Apalutamide - JNJ-56021927
- Soluble in DMSO
- MF: C21H15F4N5O2S
- MW: 477.43
Description
ARN 509 (Apalutamide) is a potent competitive androgen receptor (AR) antagonist. It inhibits androgen-dependent AR signaling and is pharmacologically relevant to both castration-sensitive and castration-resistant prostate cancer models.
Androgen receptor signaling drives prostate epithelial biology and prostate cancer growth. ARN 509 is used to investigate AR blockade, ligand-dependent transcriptional regulation and resistance mechanisms in hormone-driven oncology research.
Key Features
- Potent androgen receptor antagonist
- Blocks androgen-dependent AR signaling
- Relevant to prostate cancer pharmacology
- Useful for hormone-driven transcriptional pathway studies
Applications
- Androgen receptor binding and transcription assays
- Prostate cancer model research
- Castration-resistant prostate cancer studies
- Antiandrogen drug-response profiling
More Information
| Parent CAS No. | 956104-40-8 |
|---|---|
| Chemical Name | 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide |
| SMILES | C1(=O)N(C2C=C(C(F)(F)F)C(C#N)=NC=2)C(=S)N(C2C=C(F)C(C(=O)NC)=CC=2)C21CCC2 |
| MFCD | N.A. |
| InChi | InChI=1S/C21H15F4N5O2S/c1-27-17(31)13-4-3-11(8-15(13)22)30-19(33)29(18(32)20(30)5-2-6-20)12-7-14(21(23,24)25)16(9-26)28-10-12/h3-4,7-8,10H,2,5-6H2,1H3,(H,27,31) |
| InChiKey | HJBWBFZLDZWPHF-UHFFFAOYSA-N |
| CID | 24872560 |
| Short Description | Androgen antagonist |
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