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RD 162
- Soluble in DMSO
- MF: C22H16F4N4O2S
- MW: 476.45
Description
RD 162 is a potent and orally active androgen receptor (AR) antagonist developed as a second-generation antiandrogen research compound.
Androgen receptor signaling is a central driver of prostate cancer growth and therapeutic resistance. RD 162 is useful for studying ligand-dependent AR activation, nuclear receptor antagonism and mechanisms relevant to advanced prostate cancer models.
Key Features
- Potent antagonist of the androgen receptor
- Second-generation antiandrogen pharmacology
- Blocks AR-dependent transcriptional signaling
- Relevant to prostate cancer resistance research
Applications
- Androgen receptor pharmacology
- Prostate cancer model studies
- Antiandrogen mechanism and resistance assays
- Nuclear receptor signaling research
More Information
| Parent CAS No. | 915087-27-3 |
|---|---|
| Chemical Name | 4-[7-(4-Cyano-3-trifluoromethyl-phenyl)-8-oxo-6-thioxo-5,7-diaza-spiro[3.4]oct-5-yl]-2-fluoro-N-methyl-benzamide |
| SMILES | C1C=C(C(=O)NC)C(F)=CC=1N1C2(CCC2)C(=O)N(C2C=C(C(F)(F)F)C(C#N)=CC=2)C1=S |
| MFCD | MFCD17392574 |
| InChi | InChI=1S/C22H16F4N4O2S/c1-28-18(31)15-6-5-14(10-17(15)23)30-20(33)29(19(32)21(30)7-2-8-21)13-4-3-12(11-27)16(9-13)22(24,25)26/h3-6,9-10H,2,7-8H2,1H3,(H,28,31) |
| InChiKey | JPQFGMYHKSKKGW-UHFFFAOYSA-N |
| CID | 11957756 |
| Short Description | Antiandrogen |
References
- C Tran et al. Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science 2009, 324 (5928), 787-790.
- C Harrison. Anticancer drugs: New approaches to anti-androgen activities. Nature Reviews Drug Discovery 2009, 8, 452-453.
- CJ Hoimes and WK Kelley. Redefining hormone resistance in prostate cancer. Ther Adv Med Oncol. 2010, 2(2), 107–123.
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