Bentamapimod - AS 602801

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2002

CAS [848344-36-5]

MF C25H23N5O2S
MW 457.55

Purity: 98%
Soluble in 0.1N HCl(aq) and DMSO

Bentamapimod

Description

Potent, orally active and selective Jun kinase (JNK) inhibitor, which inhibited JNK1, JNK2 and JNK3 with IC50 values of 80, 90 and 230 nM respectively. It blocked T-lymphocyte proliferation and induced apoptosis

S Halazy. Designing heterocyclic selective kinase inhibitors: from concept to new drug candidates. ARKIVOC 2006 (vii) 496-508.

C Chiara Ferrandi et al. Characterization of immune cell subsets during the active phase of multiple sclerosis reveals disease and c-Jun N-terminal kinase pathway biomarkers. Mult. Scler. J. 2011, 17(1), 43-56.

SS Bhagwat. Chapter 17 MAP Kinase Inhibitors in Inflammation and Autoimmune Disorders. Ann. Rep. Med. Chem. 2007, 42, 265-278.

Apoptosis Cell Signaling & Oncology Immunology Pain & Inflammation MAPK (JNK) p53-Tumor Suppression NF-κB MAPK EC 2.7.11.24

JNK inhibitor, which inhibited JNK1, JNK2 and JNK3

Chemical name

2-(benzo[d]thiazol-2-yl)-2-(2-(4-(morpholinomethyl)benzyloxy)pyrimidin-4-yl)acetonitrile

Parent CAS No.

[848344-36-5]

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Size	Unit Price	Stock
5 mg	€70.00	In Stock
25 mg	€210.00	In Stock

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Size	Unit Price	Stock
2 x 5 mg	€100.00	In Stock
2 x 25 mg	€300.00	In Stock

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Bentamapimod - AS 602801

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Bentamapimod - AS 602801

Description

Chemical name

Parent CAS No.

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