LY 2886721 hydrochloride

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1964

CAS [1262036-49-6]

MF C18H16F2N4O2S.HCl
MW 426.87

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO

LY 2886721 hydrochloride

Description

Orally active cell-permeable inhibitor of human β-secretase (BACE-1); potential agent to treat Alzheimer's Disease

M Townsend. When will Alzheimer's disease be cured? A pharmaceutical perspective. J. Alzheimers Dis. 2011, 24 (Suppl 2), 43-52.

P May et al. Preclinical characterization of LY2886721: A BACE1 inhibitor in clinical development for early Alzheimer's disease. Alzheimer's & Dementia 2012, 8(4), 95.

B Willis et al. Central BACE1 inhibition by LY2886721 produces opposing effects on APP processing as reflected by cerebrospinal fluid sAPPalpha and sAPPbeta. Alzheimer's & Dementia 2012, 8(4), 582.

F Martenyi et al. BACE inhibitor LY2886721 safety and central and peripheral PK and PD in healthy subjects (HSs). Alzheimer's & Dementia 2012, 8(4), 583.

BACE 1 inhibitor

Chemical name

N-(3-((4aS,7aS)-2-amino-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide hydrochloride

Parent CAS No.

[1262036-50-9]

Order

Size	Unit Price	Stock
5 mg	€105.00	In Stock
25 mg	€365.00	In Stock

Special Offers

Size	Unit Price	Stock
2 x 5 mg	€160.00	In Stock
2 x 25 mg	€560.00	In Stock

Need more? Bulk Inquiry

Related Products

Axon ID	Name	Description
1125	BACE-1 Inhibitor	BACE 1 inhibitor	€110.00
1375	Ivachtin	Caspase-3 inhibitor	€55.00
1442	Caprospinol	Alzheimer's disease therapeutic and antihistaminergic drug	€110.00
1445	Dimebon	Alzheimer's disease therapeutic	€60.00
1484	DAPT	γ-Secretase inhibitor	€90.00
1487	γ-Secretase Inhibitor BZ	γ-Secretase inhibitor (GSI)	€90.00
1488	γ-Secretase Inhibitor DBZ	γ-Secretase inhibitor (GSI)	€80.00
1743	PAC 1	Procaspase activating compound 1	€80.00
2117	Begacestat	Selective γ-secretase inhibitor (GSI)	€85.00
2158	Boc-D-FMK	Broad spectrum caspase inhibitor	€110.00
2159	Z-VAD-FMK	Pan-caspase inhibitor with in vivo activity	Inquire
2225	LY 2811376	The first orally available non-peptidic BACE 1 inhibitor	€125.00
2303	R 55	Retromer stabilizing pharmacological chaperone. Potential Alzheimer's therapeutic	€95.00
2521	RO 4929097	Potent γ-secretase inhibitor (GSI) targeting Notch signaling in various tumor cells	€135.00
2859	J147	Potent and orally active neurotrophic drug	€90.00
2869	LX2343	BACE 1 inhibitor	€125.00
2957	BACE-2 Inhibitor	Potent and highly selective BACE 2 inhibitor	€140.00
4166	Verubecestat	First-in-class, potent, orally bioavailable high-affinity BACE1 inhibitor	€80.00

Customer Support

Customer Services

About Axon Medchem

Contact Us

LY 2886721 hydrochloride

Description

Chemical name

Parent CAS No.

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Customer Support

Customer Services

About Axon Medchem

Contact Us

LY 2886721 hydrochloride

Description

Chemical name

Parent CAS No.

Related Products

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Send us a message

Contact Us